For the full VITAL History timeline please view our History of VITAL page.
The VSEP reviewed the data from clinical (low-dose oral) food challenges from both published and unpublished studies. The papers were sourced from Australia, the United States and the European Union and over 3,400 clinical data points were collated. The data included in the review was required to meet defined quality criteria to ensure that resulting allergen thresholds were statistically sound. The data set was analysed by applying a new Stacked Model Averaging program (Wheeler et al, 2019) for each allergenic food. The Stacked Model Averaging program produces a single curve for each allergen from which Eliciting Doses may be derived. The VSEP identified the ED01 (which is the dose of the total allergen protein that is predicted to produce objective symptoms in 1% of the allergic population) which were adopted as the Reference Doses for VITAL 3.0. Wheeler et al (2021) Bayesian Stacked Parametric Survival with Frailty Components and Interval-Censored Failure Times: An Application to Food Allergy Risk, Risk Analysis, Vol. 41, No. 1, 2021.
The following papers discuss the process for how the Reference Doses within VITAL 3.0 were developed.
